CD274 and neoplasm: In analyzing the distance from PD-L1- tumor cells to PD-L1- and PD-L1+ macrophages (Figures 5A–D), we found that the PD-L1- macrophages were farther away from the PD-L1- tumor cells compared with PD-L1+ macrophages at baseline (p = 0.005, Figure 5E and Table 2).