Notably, FBXO22 expression was closely correlated with the infiltration of a variety of immune cells, including B cells, CD8+ T cells, CD4+ T cells, NK cells, macrophages, neutrophils, and dendritic cells, implicating that it might be involved in the reprogramming of the tumor immune microenvironment in PDAC. This evidence concerns the gene FBXO22 and neoplasm.