With regards to the neurobehavioral features seen in 22q11.2 deletion syndrome, the roles of COMT (catechol-O-methyltransferase) and PRODH (proline dehydrogenase) have been investigated, given their relevance to dopaminergic and glutamatergic neurotransmission, respectively. The gene discussed is PRODH; the disease is 22q11.2 deletion syndrome.