Also several research teams reported an increased intestinal permeability in ME/CFS patients supporting the widespread hypothesis of bacterial translocation into the systemic circulation (6, 9, 23, 97), in order to explain the abnormally increased levels of IgA and IgM against LPS in peripheral blood of ME/CFS patients would not be possible (67% and 40% of ME/CFS patients showed increased IgA levels and IgM levels, respectively, compared to 0% in controls). This evidence concerns the gene CD40LG and myalgic encephalomeyelitis/chronic fatigue syndrome.