As shown by the NAFLD activity scores in Figure 2F, under hepatic HE staining, we observed ballooned hepatocytes (red arrows), steatosis, and lobular inflammation (black arrows) in HFD-fed mice, indicating the formation of non-alcoholic steatohepatitis; however, Api supplementation blocked the development. Here, SERPINF2 is linked to metabolic dysfunction-associated steatohepatitis.