LGALS3 and Aganglionic megacolon: When the impact of galectin-3 on digestive manifestations of chronic T. cruzi infection was studied, it was observed that the myenteric plexus ganglia in biopsied fragments of the colon from patients with megacolon presented higher expression of galectin-3 along with galectins-1 and 9 (Beghini et al., 2017).