Finally, da Silva et al. (2017) also showed, using an infection model of the T. cruzi CL strain, that the absence of galectin-3 increased the replication of intracellular parasites in mouse peritoneal macrophages and cell lysis while augmenting blood parasite levels and reducing mast cell recruitment to the heart (da Silva et al., 2017). Here, LGALS3 is linked to infection.