After 6 h post-infection, galectin-3, but not the lysosomal membrane proteins (LAMP)-2, was found to be accumulated around T. cruzi amastigotes, supporting the notion that this lectin encloses the parasite that has recently lysed the phagolysosome and escaped to the cytoplasm (Machado et al., 2014). Here, LGALS3 is linked to infection.