LGALS3 and Chagas disease: Although galectin-3 was mainly upregulated in the group of patients presenting megacolon with intact intestinal mucosa but not in those with an ulcerated intestinal mucosa and/or mucosal hypertrophy, it has been proposed that this lectin could be a key factor implicated in the progression of colon pathology in the context of Chagas disease (Garvil et al., 2020).