INS and type 1 diabetes mellitus: Both BGL and BW values were consistent with the decline in insulin levels (8-fold, p <0.001) and the increase in HbA1C (2-fold, p < 0.0001), and Glucagon (>3-fold, p<0.01), biomarkers of T1D, measured after animals had been euthanized (Figures 1C–F).