PDE4B and type 2 diabetes mellitus: It was revealed that SRR, PDE4B, and NFKB1 variants were involved in interactions with known T2DM-associated genes, including AK3, DISC1, ADK, ASPH, SDS, RELB, HDAC1, REL, and EP300. The dysregulation and functional abnormality of these differential genes have been investigated in T2DM development (43–45).