The current study not only revealed that upregulation of T cell receptor signaling pathway components might be the major pathological mechanism underlying GDM but also suggested that circRNAs circ-CBLB, circ-ITPR3, circ-ICAM1, and their related linear transcripts CBLB, ITPR3, NFKBIA, and ICAM1 might be potential biomarkers for GDM. This evidence concerns the gene NFKBIA and gestational diabetes.