In tumor microenvironment and angiogenesis, mTORC1 under a hypoxic condition promotes the translation of hypoxia-inducible factor (HIF) 1-2, which lead to the expression of angiogenic growth factors such as vascular endothelial growth factor (VEGF), TGF-α, and platelet-derived growth factor β (PDGF-β) (32). Here, SETD2 is linked to neoplasm.