The NGAL in E and/or S fraction was higher in older participants with higher years of T1DM evolution and showed a positive correlation with the median of the HbA1c one year before enrollment, serum creatinine, and Tanner stage, but not with ACR, MAU, GFR, and HbA1 at enrollment, supporting previous findings that NGAL could be an early biomarker of DKD (46, 52). The gene discussed is LCN2; the disease is diabetic kidney disease.