PLXNA3 and peritonitis: Since sex hormones are known to affect 5-LOX product levels in vitro and in vivo, where androgens such as 5α-DHT act as endogenous suppressors in neutrophils, monocytes, and macrophages (Pace et al., 2017a; Pergola et al., 2008; Pergola, et al., 2011), and progesterone down-regulates LTs in monocytes (Pergola et al., 2015), we studied how ablation of sex hormone production in mice would affect LM levels during subsequently induced peritonitis.