Since sex hormones are known to affect 5-LOX product levels in vitro and in vivo, where androgens such as 5α-DHT act as endogenous suppressors in neutrophils, monocytes, and macrophages (Pace et al., 2017a; Pergola et al., 2008; Pergola, et al., 2011), and progesterone down-regulates LTs in monocytes (Pergola et al., 2015), we studied how ablation of sex hormone production in mice would affect LM levels during subsequently induced peritonitis. Here, ALOX5 is linked to peritonitis.