In another study, it has been reported that oral administration of O. basilicum seed extract (on days 25, 27, and 29 from 30 days of sensitization period) inhibits the expression of Th2 upstream cytokines such as IL-8, IL-9, IL-11, IL-25, IL-33, and eotaxin and hyperplasia in goblet cell in an animal model of OVA-induced allergic asthma. The gene discussed is CXCL8; the disease is allergic asthma.