IGHE and asthma: In a rat model of asthma induced by OVA, O. basilicum hydroethanolic extract (0.75, 1.50, and 3.00 mg/ml) in drinking water, for 21 days during the sensitization period, reduced IL-4, PLA2, IgE, and total protein (TP) levels but enhanced the IFN-γ/IL-4 ratio in a dose-dependent manner.