Various immunomodulators are used for the treatment of respiratory diseases, including omalizumab, an anti-IgE antibody; benralizumab, mepolizumab, and reslizumab, IL-5 antibodies; and dupilumab, an IL-4 and IL-13 inhibitor monoclonal antibody which is used for the treatment of allergic asthma; some other antibodies are used for the treatment of other respiratory disorders such as lung infection and lung cancer (Desoubeaux et al., 2016). This evidence concerns the gene IGHE and respiratory system disorder.