CDH1 and breast cancer: Many have noted that overexpression NAT1, specifically in breast cancer, is associated with increased metastasis (Smid et al., 2006; Savci-Heijink et al., 2016; Zhao et al., 2020) and growth (Adam et al., 2003) and conversely knockdown or deletion of NAT1 leads to increased adherence to collagen (Li et al., 2020) and decreased invasion (Tiang et al., 2010, 2015; Li et al., 2020), E-cadherin up-regulation and cell-cell contact growth inhibition (Tiang et al., 2011), and reduced anchorage independent growth (Stepp et al., 2018; Stepp et al., 2019).