For example, berberine exerts anticancer activity on CRC both in vivo and in vitro by inhibiting PI3K/AKT signaling and by downregulating insulin-like growth factor 2 (IGF2) mRNA-binding protein 3 (IGF2BP3) (Zhang Y. et al., 2020), a member of the oncofetal RNA-binding protein family, and is highly expressed in many different types of cancers (Mancarella et al., 2018). This evidence concerns the gene IGF2 and cancer.