In MKN-45-related gastric cancer, which harbors wild type p53, epiberberine shows great potential in inhibiting cell growth by inducing ROS, mitochondrial apoptosis and cell cycle arrest in vitro and inhibiting tumor growth in vivo via the p53/Bax pathway, and also inhibiting cell growth in the human gastric cancer (HGC-27) cells, which harbors mutated p53 (Zhai et al., 2020). Here, BAX is linked to gastric cancer.