APOE and atherosclerosis: In this study, our data firstly demonstrated that ginsenoside Rb2 reduced macrophages infiltration and pro-inflammatory M1 phenotype polarization, inhibited lipid accumulation, increased the collagen content in plaque lesions, and thus alleviated the plaque instability and atherosclerosis progression through neutralizing the effects of miR-216a in the ApoE−/− atherosclerotic mice model.