Within the infarcted area of AMPKα1-deficient mouse hearts, collagen cross-linking and myodifferentiation are remarkably decreased, causing faulty scar collagen maturation, compromised scar contractility, and worsening LV dilatation 30 days post-MI (Noppe et al., 2014). The gene discussed is PRKAA1; the disease is myocardial infarction.