AMPK as a key player in metabolic pathways, has a vital function in various cellular processes to protect against cardiac hypertrophy, through regulating energy supply, protein synthesis, autophagy, cytoskeletal network expansion, transcription, ER stress, and microRNA expression (Frey and Olson 2003; Horman et al., 2012). Here, PRKAA2 is linked to hypertrophy.