AMPK as a key player in metabolic pathways, has a vital function in various cellular processes to protect against cardiac hypertrophy, through regulating energy supply, protein synthesis, autophagy, cytoskeletal network expansion, transcription, ER stress, and microRNA expression (Frey and Olson 2003; Horman et al., 2012). The gene discussed is PRKAA2; the disease is cardiac hypertrophy.