The main findings of this study are as follows: 1) DSELD protects H9C2 cells from CM-induced injuries; 2) DSELD restores the cardiac functions and reverses the pathological damages in a mouse model of myocardial hypertrophy; 3) DSELD modulates the levels of multiple inflammatory cytokines; 4) DSELD inhibits inflammation by downregulating the expression of inflammatory proteins such as MyD88 and MMP9, key components of the TLR4 signaling pathway. This evidence concerns the gene TLR4 and cardiac hypertrophy.