Animal models, such as P301L and P301S, that recapitulate pathological features of 4R tauopathy have been developed with mutations in the MAPT gene, (Lewis et al., 2000; Gotz et al., 2001; SantaCruz et al., 2005; Spires et al., 2006), as well as hTau and knock in animal models (Saito et al., 2019; Hosokawa et al., 2021). The gene discussed is MAPT; the disease is tauopathy.