MAPT and neurodegenerative disease: The challenges of α-synuclein imaging stem from the intracellular location of α-synuclein inclusions, distinct α-synuclein strains, presence across different neurodegenerative diseases, and difficulty in finding a tracer with selectivity to α-synuclein over Aβ and tau fibrils (Yamasaki et al., 2019; Berg et al., 2021).