AQP4 and demyelinating disease of central nervous system: In a retrospective cohort study from the Mayo Clinic, comparing the evolution of MRI lesions in different central nervous system demyelinating disorders, MRI normalisation of brain T2 signal abnormality was more common with MOGAD for brain attacks (MOGAD, 39%; AQP4-IgG-NMOSD, 10%; Multiple sclerosis, 5%), and the greater remyelination capacity, less neuronal loss, or a predominant functional vs. structural damage in MOGAD might account for this difference (Sechi et al., 2021).