Regulation of the expression of ADAM10, presenilin and the amyloid precursor protein (Seipold and Saftig, 2016). Associated with progression of acute myeloid leukemia (Kwon et al., 2015; Yang et al., 2016; Sun et al., 2020; Zhang Z. Y. et al., 2020). Here, APP is linked to acute myeloid leukemia.