Promotes metastasis of hepatocellular carcinoma through Notch signaling (Xie et al., 2021). Involved in dendritic spine maturation process (Moretto et al., 2019). Plays a role in regulation of ADAM10 compartmentalization (Jouannet et al., 2016) and trafficking (Dornier et al., 2012) to the cell surface. Here, ADAM10 is linked to hepatocellular carcinoma.