TSPAN6 and developmental and epileptic encephalopathy, 9: Tspan6, associated with the neurological condition EFMR (epilepsy female-restricted with mental retardation, now referred to as intellectual disability), has been identified as a novel regulator of hippocampal synaptic transmission and LTP, with a key role in synapse development and AMPAR trafficking (Depienne et al., 2011; Vincent et al., 2012; Salas et al., 2017).