In a high-grade glioma mouse model harnessing the potential of Hypericin-PDT based DC vaccines, these vaccines reduced the immunosuppressive GBM burden and synergized with the anti-GBM action of temozolomide and resulted in an increased overall mice survival of approximately 300% [127] Interestingly, the efficacy of stressed/dying cells after Hypericin-PDT to induce DC maturation and the overall efficiency of DC vaccines, were abolished by the neutralization of the main ICD-associated DAMPs namely HMGB1, ATP and CRT [128]. This evidence concerns the gene CALR and central nervous system cancer.