Necroptosis is ‘programmed’’ by the activation/phosphorylation of receptor-interacting protein kinase-1 (RIPK-1), RIPK-3, and mixed lineage kinase domain-like pseudokinase regulated pathway, ultimately causing the permeabilization of plasma membrane [55], Necroptosis is an alternative RCD that could elicit ICD [56] especially in apoptosis-resistant cancer cells subpopulations [57–59]. Here, RIPK1 is linked to cancer.