During ICD, ATP secreted by stressed cells, by binding to purinergic receptors (P2RY2 and P2RX7) on the surface of DCs, acts as ‘find-me’’ signal to recruit DCs to the site of dying cancer cells and stimulates the assembly and activation of the inflammasome, leading to the production and secretion of interleukin (IL)-1β [35] by DCs. The gene discussed is P2RY2; the disease is cancer.