In hepatocellular carcinoma and clear cell renal cell carcinoma, the mRNA levels of Ezh2 and FBP1 are inversely correlated due to the presence of the EZH2-dependent H3K27me3 repressive mark at the promoter of the gluconeogenic enzyme-coding gene.180 Tumor growth was shown to be thwarted either by a short-hairpin RNA (shRNA) directed against Ezh2, or by the reintroduction of FBP1. Here, EZH2 is linked to clear cell renal carcinoma.