SUZ12 and leukemia: While their target genes are overlapping,34,116 their differences rely on their affinity to chromatin.117 Indeed, PRC2.1 tends to have a higher affinity to chromatin, which leads to an increase in H3K27me3 deposition and silencing of PcG target genes in the presence of high ratios of PRC2.1 to 2.2.117 In leukemia, colon and uterine adenocarcinomas, missense mutations of SUZ12, SUZ12(R103P/Q), result in JARID2 depletion, leading to an increase in PRC2.1 formation which enhances PRC2 chromatin occupancy.117 How PRC2.1 could be specifically implicated in cancer remains to be determined.