Additionally, SUZ12 is upregulated in a variety of cancers, including ovarian, colorectal and head and neck squamous cell carcinoma.113–115 The knockdown of SUZ12 is able to reverse tumor growth by inhibiting proliferation and inducing apoptosis in these contexts.113,115 On the other hand, SUZ12 loss in T-ALL disrupts the PRC2 complex, leading to H3K27me3 decrease which correlates with the opening of chromatin and upregulation of the corresponding genes involved in oncogenic signaling pathways92 (Fig. 3a). Here, SUZ12 is linked to acute lymphoblastic leukemia.