EZH2 and cancer: Cancer cells with higher levels of LAT1 expression have a more aggressive phenotype.172 Upon LAT1 depletion, the SAM pool is significantly reduced, correlating with a decrease in H3K27me3 deposition even if EZH2 protein concentration is constant.172 In addition, repression of RXRα, a known negative regulator of LAT1, by the PRC2 complex maintains a positive feedback loop between LAT1 and EZH2, enhancing EZH2 methyltransferase activity172 (Fig. 5a).