BAP1 and neoplasm: Likewise, MGA, a transcription factor that is a member of the Myc network and interacts with ncPRC1.6 subunits, is a tumor suppressor in vivo that acts by recruiting ncPRC1.6 to its target genes.143 Moreover, BAP1, a component of the Polycomb Repressive complex DeUbiquitinase (PR-DUB), is a tumor suppressor.144,145 Recent data suggest that this protein prevents widespread H2AK119ub deposition and chromatin condensation at non-target loci, restricting H2AK119ub to Polycomb target genes.