In Testicular Germ Cell Tumors (TGCT), resistance to cisplatin is accompanied by a global decrease in H3K27me3 and H2AK119Ub levels, leading to upregulation of Polycomb target genes.223 Inhibition of the UTX and JMJD3 enzymes, responsible for H3K27 demethylation, is sufficient to increase H3K27me3 and make TGCT cells more sensitive to the initial chemotherapy.223. This evidence concerns the gene KDM6A and testicular germ cell tumor.