In patients with advanced prostate cancer, H3K36me3 and H3K27me3 levels are inversely correlated.78,111 SETD2, the methyltransferase responsible for H3K36me3 deposition, also monomethylates EZH2 on its lysine 735 residue, inducing EZH2 degradation and consequently delaying metastasis. Here, SETD2 is linked to prostate cancer.