Several recent studies have demonstrated that either nAb or RBD-specific antibody titer is closely correlated with vaccine-induced protective immunity in humans and NHPs.77,78 Here we found that nAbs in the sera of CF501/RBD-Fc-vaccinated rabbits and rhesus macaques could potently neutralize infection of the 4 authentic SARS-CoV-2 VOCs, 9 pseudotyped SARS-CoV-2 VOCs/VOIs, and 41 pseudotyped SARS-CoV-2 mutants with a single natural mutation in S protein. The gene discussed is PROS1; the disease is infection.