Paltoglou et al.15 reported that transcription factor Grainyhead-like 2 (GRHL2) plays a multifaceted role in prostate cancer, enhancing the oncogenic androgen receptor (AR) signaling pathway and promoting tumor growth, as well as suppressing metastasis-related phenotypes by suppressing epithelial-mesenchymal transition and cell invasion. The gene discussed is AR; the disease is prostate cancer.