The expression of tumor molecular clock was significantly reduced compared to healthy skin but still displayed an oscillatory profile (attenuated PER1 and BMAL1 oscillations)50,51. Although not affecting the core clock machinery, Masri et al. also found that lung cancer induced significant shifts in liver circadian rhythms, both at the level of transcripts and metabolites including AAs in tumor-bearing mice. This evidence concerns the gene PER1 and lung carcinoma.