Among these hyperlipidemia-associated five loci, a mechanism has been established for only rs780092 (2p23.3), owing to LD with rs780094 (r2 = 0.45 in EAS of the 1000 Genomes Project); rs780094 facilitates the binding of transcription factor FOXA2 to regulate GCKR expression16. The gene discussed is GCKR; the disease is hyperlipidemia.