Subsequently, we wanted to explore the relationship of the DDX39B protein expression levels between the colorectal cancer tissues and normal tissues, so we found some Immunohistochemistry staining images of DDX39B in the HPA (Human Protein Atlas) database, we can obviously find that the colorectal cancer tissues showed the higher staining intensity of DDX39B which is mainly located in the nucleus than the normal tissues (Fig. 1D). The gene discussed is DDX39B; the disease is colorectal cancer.