There is extensive information about the role of SPOCK1 in the tumour extracellular matrix (ECM) dynamic homoeostasis process, which activates many molecular signalling pathways (such as EMT process, Wnt/β-catenin, PI3K/Akt and mTOR/S6K signalling pathways) [53, 55, 57, 67]. Here, AKT1 is linked to neoplasm.