Previous studies have suggested that elevated levels of tumor-infiltrating CD8+ CTLs are closely related to the antitumor effects of various cancer types, including melanoma, skin cancer, colon cancer et.al.56 The unique mechanism of IL-37 act on cytotoxic CD8+ T cells provides a powerful basis for development of clinically antineoplastic agent for the different types of cancer. This evidence concerns the gene IL37 and skin neoplasm.