IL-18, which binds the IL-18 receptor 1 (IL-18Rα), synergistically enhances IFN-γ secretion from CD8 T cells,35 it plays an essential role in protection against colorectal tumor development.10,12 The expression of IL-18 was increased in colon of CAC model (Supplementary Fig. S7a). Here, CD8A is linked to colorectal neoplasm.