In addition, the presence of a low percentage of effector and/or effector memory (CD62LnegCD44high) and central memory (CD62L+CD44high) CD8 T cells was observed in MLN of IL-37tg mice compared with those in WT mice (Fig. 3f), which is linked to poor prognosis in human CRC patients.34 Similar to the results obtained for MC38 xenograft model, we found that the frequency of CD8+ T cells and CD8+IFN-γ+ T cells was significantly decreased in tumors and tumor-draining lymph nodes of IL-37tg mice compared with that of WT mice (Supplementary Fig. S6d–f). The gene discussed is CD8A; the disease is colorectal carcinoma.