Previous research has indicated that levels of DNA mismatch repair gene expression in epithelial cells after DNA damage is associated with frequency of oncogenic mutations induced by AOM.26 We found a similar mismatch DNA repair genes expression in tumors of IL-37tg mice and WT mice, including poly ADP-ribose polymerase (Parp) family members (Parp1, msh2) and mismatch repair (MMR) proteins (Msh3, Mlh1), as well as genes involved in double-strand DNA repair (ataxia telangiectasia mutated, Atm; ataxia telangiectasia and Rad3 related, ATR) (Supplementary Fig. S3c). Here, MSH3 is linked to infectious otitis media.