Considering the anti-inflammatory properties of IL-37, it has been found that IL-37 can influence the development of some cancers, such as non-small cell lung cancer, hepatocellular carcinoma, cervical cancer, and colon cancer.21,22 However, immunological roles and functional mechanism of IL-37 have remained elusive in tumor microenvironment. The gene discussed is IL37; the disease is non-small cell lung carcinoma.