Feng et al. indicated that IL-37 diminished Th1 response but promoted the Th2 cytokines (IL-13 and IL-4) production in ConA induce liver injury.18 IL-37 stimulation elevated the Tregs cell proportion in subjects with infectious disease and hypersensitivity.19,20 These findings suggested IL-37 function as important regulatory factor on T cell immune response. The gene discussed is IL37; the disease is injury.