Moreover, CD8+ T cells from IL-37tg mice exhibited decreased expression of CD69 and IFN-γ, frequency of OVA-specific CD8+ T (Tetramer+CD8+) cells was lower in IL-37tg mice compared with that of control groups (Fig. 4b, c), these results indicated that IL-37 inhibits the functional efficacy of tumor-specific CD8 T cells. This evidence concerns the gene CD8A and neoplasm.