IL18 and colitis: In DSS model, IL-18 secretion was significantly induced,48,50 and IL-18 can mediate intestinal epithelial cell proliferation and tissue repair following DSS injury, and thereby leads to attenuates symptoms of colitis.48,50–52 For IL-37tg mice, we found that the expression level of IL-37 was significantly higher in colon after treatment with DSS than steady state.