MYC and neoplasm: LV-IL-37/LoVo cells and LV-Ctrl/LoVo cells have similar c-myc as well as p-p65, pSmad3L and pSmad3C level (Supplementary Fig. S4h, I), although IL-37 inhibited liver tumor growth via converting pSmad3 isoform pathway from pSmad3L tumor-promoting signal to pSmad3C tumor-suppressing signal.27 These results can be drawn that overexpression of IL-37 has negligible effects on proliferation, apoptosis and motility of colon carcinoma cells at rest state.