ITGAE and neoplasm: And a significant decrease was observed in the percentage of CD8+ T cells expressing CD103 (integrin associated with intestinal T cell retention), CD69 (early activation marker), CD107 (degranulation marker), or IFN-γ (effector cytokine) was observed in tumor-bearing colon tissue of IL-37tg mice compared with those of WT mice (Fig. 3e).