Myeloid-derived suppressor cells (MDSCs) can dominate tumor immunosuppressive microenvironment, it has a suppressive ability on CD8+ or CD4+ T cells in AOM/DSS-induced CAC.30,31 However, we did not observe significantly different levels of CD11B+Gr-1+ MDSCs in tumor-bearing colon tissue of IL-37tg mice and WT mice (Fig. 3d). Here, CD4 is linked to neoplasm.