In humans, plasticity of macrophages is far more complex.54 For example, macrophages co-expressing CD206 and MMP-9 have been observed in GCA lesions41 and a population of pro-inflammatory CD14+ HLA-DRhigh CD206+ macrophages has been identified in human viral hepatitis.55 Overall, mavrilimumab decreased the inflammatory and destructive potential of macrophages. This evidence concerns the gene MRC1 and animal viral hepatitis.