KRAS and non-small cell lung carcinoma: In preclinical studies, LY3537982 inhibited KRAS-GTP loading in the KRASG12C mutant H358 NSCLC cell line with an IC50 value of 3.35 nM, while AMG510 and MRTX849 had IC50 values of 47.9 nM and 89.9 nM, respectively.