DUSP6 and non-small cell lung carcinoma: In a panel of KRASG12C NSCLC cell lines, treatment with BI 1823911 resulted in downregulation of MAPK pathway-responsive genes, such as DUSP6 and CCND1. In addition, at the protein level, strong and sustained inactivation of the MAPK pathway was observed using p-ERK as a pharmacodynamic biomarker.