RAS proteins play a pivotal role in the regulation of cell proliferation, differentiation, and survival that drive multiple aspects of transformation and tumor progression through these signal transduction cascades, which include the canonical RAF–MEK–ERK/MAPK, PI3K–AKT–mTOR, and RALGDS–RAL pathways, among others (Fig. 2) [19, 30–35]. This evidence concerns the gene MAP2K7 and neoplasm.