FZD7 and intrahepatic cholangiocarcinoma: Depending on the different subcellular locations, circACTN4 could interact with YBX1 to coactivate the transcription of FZD7 in the nucleus and sponge miR-424-5p to upregulate the mRNA level of YAP1 in the cytoplasm, thereby facilitating the development and progression of intrahepatic cholangiocarcinoma [47].