A previous study demonstrated that circ-CCAC1 elevated YY1 expression to promote cholangiocarcinoma (CCA) by sponging miR-514a-5p in CCA cells while elevating SH3GL2 expression to enhance cell permeability by directly sequestering EZH2 in the cytoplasm of human umbilical vein endothelial cells [46]. The gene discussed is EZH2; the disease is cholangiocarcinoma.