In this trial, while the primary endpoint is the proportion of patients achieving a reduction in the total symptom score ≥ 50% from baseline at week 24, key secondary endpoints include the proportion of transfusion-independent patients (defined as not requiring a RBC transfusion for ≥ 12 weeks and having Hb ≥ 8 g/dL at week 24) and the proportion of patients who achieve spleen volume reduction ≥ 35% from baseline at week 24; and other measures of anemia benefit, such as Hb improvement and cumulative transfusion burden [90]. Here, GSTM1 is linked to anemia.