All these genes were reported to be associated with risk factors for heart failure such as BMI (GRM4, SLC25A2, and ZBTB20) [40], systolic blood pressure (SLC1A4, ZBTB20, and SLC25A2) [41], ejection fraction (SLC1A4 and DLGAP1) [42], atrial fibrillation (SLC25A2 and SLC1A4) [43], coronary artery disease (ZBTB20 and SLC25A2) [44], type 2 diabetes (ZBTB20) [45], cardiac Troponin-T levels (DLGAP1) [46], diastolic blood pressure (RHOBTB1) [47], gout (CYP2E1) [48], implying the scientific validity of CpGs in model for CHF risk prediction. This evidence concerns the gene GRM4 and heart failure.