The mechanistic effects of diabetes on fewer aortic aneurysm and smaller aortic diameter included extracellular matrix remodeling, increase of glycation and advanced glycation end products, decrease of macrophage infiltration in the vascular walls, activation of the TGF-b signaling pathway, and modulation of vascular smooth muscle cells homeostasis [10]. Here, TGFB1 is linked to aortic aneurysm.