Although timely addition of insulin to oral therapy for T2DM has been recommended to prevent complications by early institution of strict glycemic control and β-cell protection [3], a substantial proportion of patients with suboptimal glucose control tend to delay insulin therapy due to fear of hypoglycemia, along with a reluctance to start injections and gain weight [6], which may further influence adherence to insulin therapy [7]. This evidence concerns the gene INS and type 2 diabetes mellitus.