The levels of METTL3, HNRNPA2B1, RBM15B, and IGFBP2 were higher, while those of ZC3H13, FTO, and IGFBP3 were lower in PCa tissues than in normal tissues (P < 0.001) (Fig. 1B and Table 2). The gene discussed is IGFBP3; the disease is posterior cortical atrophy.