Because global SWA is known to be disrupted in patients with AD (Lucey et al., 2019; Mander et al., 2015) and in fAD mouse models after the onset of cognitive decline (Kent et al., 2018), we used EEG/EMG recordings (Figures S4A–S4C) to test how global SWA is affected in APP/PS1 mice before robust cognitive impairments are evident. Here, APP is linked to familial Alzheimer disease.