Comparing aberrantly methylated sites in progeroid laminopathies, classic Werner syndrome, and Down syndrome revealed a common significantly hypermethylated region in close vicinity to the transcription start site of a long non‐coding RNA located anti‐sense to the Catenin Beta Interacting Protein 1 gene (CTNNBIP1). The gene discussed is CTNNBIP1; the disease is laminopathy.