The P681H mutation has emerged spontaneously multiple times, as early as March 2020, in places such as Nigeria (GISAID Accession ID: EPI_ISL_729975), Hawaii [15], Israel [16], multiple times in New York State [17], and in the B.1.1.7 UK strain [11]; it is of particular interest due to its proximity to the furin cleavage site of importance for infection and transmission. The gene discussed is FURIN; the disease is infection.