Moreover, Up-regulation of GPR37 (HR 1.31, P = 0.0044) and CXCL8 (HR 1.47, P = 6.6e-05) and down-regulation of FPR1 (HR 0.64, P = 0.0074), SAA1 (HR 0.66, P = 0.0017), CCR5 (HR 0.56, P = 4.9e-05), GNG2 (HR 0.56, P = 0.3.7e-05), C3 (HR 0.67, P = 3.2e-05) and PTPN6 (HR 0.7, P = 0.00023) were significantly associated with an unfavorable overall survival in breast cancer patients (Fig 8, S2 Fig). The gene discussed is C3; the disease is breast cancer.