As seen with antiviral CD4+ T cells, CD8+ T cell responses (CD8+CD69+41BB+) against SARS-CoV-2 spike–containing CD8-A MP and CD8-B MP were detectable in the majority of children with convalescent COVID-19 (74% and 75% with FC > 2, respectively; Figure 1D). Here, CD8A is linked to COVID-19.