ELANE and chronic obstructive pulmonary disease: In keeping with a potential in vivo role for hypoxic augmentation of neutrophil degranulation, we found higher levels of the granule proteins NE, MPO, and NGAL and a footprint of increased NE and PR3 activity in COPD versus healthy plasma, aligning with recent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) studies, where NGAL in particular was associated with mortality (40).