Likewise, secretion of selected granule and cytoplasmic protein targets identified by proteomics NGAL (Figure 5C) and cyclophilin A (Figure 5D) was increased 1.5- and 5-fold, respectively, from stimulated hypoxic neutrophils from patients with COPD versus healthy control subjects, with a similar pattern demonstrated for resistin release (Figure 5E). This evidence concerns the gene PPIA and chronic obstructive pulmonary disease.