Genes containing AS events associated with overall survival are known components of cancer-related pathways, including regulation of transcription (E2F4, ZNF730, GPBP1, POLR2J, SP2, and CIART), cell cycle (E2F4 and GTSE1), or cell-cell adhesion (CEACAM1, MMP14, EPS8L2, AP3D1, AFDN, and PAK4) (Fig. 4B). This evidence concerns the gene E2F4 and cancer.