We found 183 peptides with 313 unique mutations, at 253 sites (Appendix Fig S9), including missense mutations of the TNK1‐binding peptide from the SH3‐binding protein 2 (SH3BP2 408‐PQLPHLQRSPPDGQSF‐423; affected residues underlined) that are known to abrogate the interaction with TNKs and are associated with cherubism (Ueki et al, 2001; Imai et al, 2003; Lo et al, 2003). The gene discussed is TNKS; the disease is cherubism.