Other reported roles include the control of histone mono-ubiquitination [24], promotion of epithelial-to-mesenchymal transition (EMT) by the stabilization of Snail1 [25], stabilization of Cyclin E (promoting growth, migration, and invasion of hepatocellular carcinoma) [26], stabilization of the cytosolic DNA-sensor cyclic GMP-AMP synthase (cGAS) [27], and the negative regulation of the cytosolic RNA-sensors RIG-1 and MDA5 [21]. Here, CGAS is linked to hepatocellular carcinoma.