Knockdown of PCTAIRE1 decreases the proliferation of several cancer cell lines, including those in cervical, prostate and breast cancers (Yanagi et al., 2017, 2014; Yanagi and Matsuzawa, 2015), and reduces tumor volumes in mouse xenograft models (Wang et al., 2017; Yanagi et al., 2016). The gene discussed is CDK16; the disease is cancer.