Since miR-490-5p was most notably under-expressed in PANC-1 cells, and the effect of miR-490-5p mimic on pancreatic cancer was performed in PANC-1 cells, we chose PANC-1 cells to further investigate the role and mechanism of miR-490-5p and MAGI2-AS3 on pancreatic cancer. This evidence concerns the gene MAGI2 and familial pancreatic carcinoma.