Individual case reports and small case series describe successful application of alemtuzumab in the setting of seropositive paraneoplastic disorders, including cancer-associated retinopathy (CAR) with detectable CAR autoantibodies [125] and desmoglein 3- and desmoplakin I- and II-positive paraneoplastic pemphigus (PNP) [126]. The gene discussed is DSG3; the disease is cancer.